The Roseoloviruses Downregulate the Protein Tyrosine Phosphatase PTPRC (CD45)
نویسندگان
چکیده
منابع مشابه
Mutation of the receptor tyrosine phosphatase PTPRC (CD45) in T-cell acute lymphoblastic leukemia.
The protein tyrosine phosphatase CD45, encoded by the PTPRC gene, is well known as a regulator of B- and T-cell receptor signaling. In addition, CD45 negatively regulates JAK family kinases downstream of cytokine receptors. Here, we report the presence of CD45 inactivating mutations in T-cell acute lymphoblastic leukemia. Loss-of-function mutations of CD45 were detected in combination with acti...
متن کاملA high-frequency polymorphism in exon 6 of the CD45 tyrosine phosphatase gene (PTPRC) resulting in altered isoform expression.
CD45 (leukocyte common) antigen is a hemopoietic cell-specific tyrosine phosphatase essential for antigen receptor-mediated signaling in lymphocytes. The molecule undergoes complex alternative splicing in the extracellular domain, and different patterns of CD45 splicing are associated with distinct functions. Lack of CD45 leads to severe combined immunodeficiency, and alterations of CD45 splici...
متن کاملCD45-associated protein inhibits CD45 dimerization and upregulates its protein tyrosine phosphatase activity Running head: CD45-AP INHIBITS CD45 DIMERIZATION
CD45, a receptor-like protein tyrosine phosphatase (PTP), plays an essential role in lymphocyte development and immune responses. Recent evidence suggests that dimerization of CD45 downregulates its function. However, the mechanisms by which CD45 dimerization is regulated remain unclear and there is no direct evidence that the PTP activity of CD45 dimers is less than that of monomers. CD45 in l...
متن کاملLYMPHOID NEOPLASIA Brief report Mutation of the receptor tyrosine phosphatase PTPRC (CD45) in T-cell acute lymphoblastic leukemia
1Center for the Biology of Disease, VIB, Leuven, Belgium; 2Center for Human Genetics, KU Leuven, Leuven, Belgium; 3Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy; 4Division of Hematology, Department of Cellular Biotechnologies and Hematology, Sapienza University of Rome, Rome, Italy; 5Inserm U944 and Hematology Laboratory, Hôpital Saint-Loui...
متن کاملIMMUNOBIOLOGY CD45-associated protein inhibits CD45 dimerization and up-regulates its protein tyrosine phosphatase activity
CD45, a receptor-like protein tyrosine phosphatase (PTP), plays an essential role in lymphocyte development and immune responses. Recent evidence suggests that dimerization of CD45 downregulates its function. However, the mechanisms by which CD45 dimerization is regulated remain unclear, and there is no direct evidence that the PTP activity of CD45 dimers is less than that of monomers. CD45 in ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Virology
سال: 2021
ISSN: 0022-538X,1098-5514
DOI: 10.1128/jvi.01628-20